Causes of ulcerative proctitis

If you experience symptoms or get a diagnosis of ulcerative proctitis, your first thought may be “why me?” The exact cause of ulcerative proctitis is unknown, but researchers believe:

  • Foreign substances (eg, bacteria or a virus) may react with the body’s immune system, triggering inflammation (swelling, usually with redness and pain) of the rectum (the area between the colon and the anus), which causes the symptoms of ulcerative proctitis
  • Ulcerative proctitis may run in families

It’s important to remember that ulcerative proctitis is not your fault. It is not caused by emotional stress or eating certain foods. However, stress and certain foods have been shown to trigger or worsen symptoms in some people.

IMPORTANT RISK INFORMATION

Do not use CANASA if you are:

  • allergic to medicines that contain salicylates, including aspirin.
  • allergic to mesalamine or any of the ingredients in CANASA. See Patient Information in the full Prescribing Information for a complete list of ingredients in CANASA.
Ask your doctor if you are not sure if your medicine is listed.

Before using CANASA, tell your doctor if you:

  • have a history of allergic reaction to the medicine sulfasalazine (Azulfidine).
  • have kidney problems.
  • have ever had inflammation of the sac around your heart (pericarditis).
  • have liver problems.
  • have any other medical conditions.
  • are pregnant or plan to become pregnant. It is not known if CANASA can harm your unborn baby.
  • are breastfeeding or plan to breastfeed. CANASA can pass into your breast milk. Talk to your doctor about the best way to feed your baby if you use CANASA.
Tell your doctor about all the medicines you take, including prescription and over-the-counter medicines, vitamins, and herbal supplements. Taking CANASA with nonsteroidal anti-inflammatory drugs (NSAIDs) may cause kidney problems. Taking CANASA with azathioprine or 6-mercaptopurine may cause blood problems. Your doctor may do certain tests during treatment with CANASA.

What are the possible side effects of CANASA?

CANASA may cause serious side effects, including:

  • Kidney Problems. Your doctor will do certain tests before you start using CANASA and during your treatment.
  • Acute Intolerance Syndrome or Other Allergic Reactions. When this happens, it is usually in people who have had an allergic reaction to sulfasalazine. Stop using CANASA and tell your doctor right away if you get any of these symptoms: cramps, stomach (abdominal) pain, bloody diarrhea, chest pain, decrease in the amount of urine, fever, headache, rash, shortness of breath, or fatigue.
  • Liver Problems. This can happen in people who have a history of liver problems and have taken other medicines that contain mesalamine. Tell your doctor right away if you get any of these symptoms while using CANASA: yellowing of your eyes, itchy skin, feeling very tired, flu-like symptoms, nausea or vomiting.
The most common side effects of CANASA include: dizziness, acne, inflammation of the large intestine (colitis), rectal pain, fever, and rash.

Tell your doctor if you have any side effect that bothers you or does not go away. These are not all of the possible side effects of CANASA.

What is CANASA?

CANASA (mesalamine) 1000 mg rectal suppository is a prescription medicine used to treat adults with active ulcerative proctitis (ulcerative rectal colitis). It is not known if CANASA is safe and effective in children.

Please also see the Patient Information within the full Prescribing Information.

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